The outburst of COVID-19 in late 2019 was the start of a health crisis that shook the world and took millions of lives in the ensuing years. Many governments and health officials failed to arrest the rapid circulation of infection in their communities. The long incubation period and the large proportion of asymptomatic cases made COVID-19 particularly elusive to track. However, wastewater monitoring soon became a promising data source in addition to conventional indicators such as confirmed daily cases, hospitalizations, and deaths. Despite the consensus on the effectiveness of wastewater viral load data, there is a lack of methodological approaches that leverage viral load to improve COVID-19 forecasting. This paper proposes using deep learning to automatically discover the relationship between daily confirmed cases and viral load data. We trained one Deep Temporal Convolutional Networks (DeepTCN) and one Temporal Fusion Transformer (TFT) model to build a global forecasting model. We supplement the daily confirmed cases with viral loads and other socio-economic factors as covariates to the models. Our results suggest that TFT outperforms DeepTCN and learns a better association between viral load and daily cases. We demonstrated that equipping the models with the viral load improves their forecasting performance significantly. Moreover, viral load is shown to be the second most predictive input, following the containment and health index. Our results reveal the feasibility of training a location-agnostic deep-learning model to capture the dynamics of infection diffusion when wastewater viral load data is provided.

Solving portfolio management problems using deep reinforcement learning has been getting much attention in finance for a few years. We have proposed a new method using experts signals and historical price data to feed into our reinforcement learning framework. Although experts signals have been used in previous works in the field of finance, as far as we know, it is the first time this method, in tandem with deep RL, is used to solve the financial portfolio management problem. Our proposed framework consists of a convolutional network for aggregating signals, another convolutional network for historical price data, and a vanilla network. We used the Proximal Policy Optimization algorithm as the agent to process the reward and take action in the environment. The results suggested that, on average, our framework could gain 90 percent of the profit earned by the best expert.

From smoothly pursuing moving objects to rapidly shifting gazes during visual search, humans employ a wide variety of eye movement strategies in different contexts. While eye movements provide a rich window into mental processes, building generative models of eye movements is notoriously difficult, and to date the computational objectives guiding eye movements remain largely a mystery. In this work, we tackled these problems in the context of a canonical spatial planning task, maze-solving. We collected eye movement data from human subjects and built deep generative models of eye movements using a novel differentiable architecture for gaze fixations and gaze shifts. We found that human eye movements are best predicted by a model that is optimized not to perform the task as efficiently as possible but instead to run an internal simulation of an object traversing the maze. This not only provides a generative model of eye movements in this task but also suggests a computational theory for how humans solve the task, namely that humans use mental simulation.

Graph convolutional neural networks have shown significant potential in natural and histopathology images. However, their use has only been studied in a single magnification or multi-magnification with late fusion. In order to leverage the multi-magnification information and early fusion with graph convolutional networks, we handle different embedding spaces at each magnification by introducing the Multi-Scale Relational Graph Convolutional Network (MS-RGCN) as a multiple instance learning method. We model histopathology image patches and their relation with neighboring patches and patches at other scales (i.e., magnifications) as a graph. To pass the information between different magnification embedding spaces, we define separate message-passing neural networks based on the node and edge type. We experiment on prostate cancer histopathology images to predict the grade groups based on the extracted features from patches. We also compare our MS-RGCN with multiple state-of-the-art methods with evaluations on both source and held-out datasets. Our method outperforms the state-of-the-art on both datasets and especially on the classification of grade groups 2 and 3, which are significant for clinical decisions for patient management. Through an ablation study, we test and show the value of the pertinent design features of the MS-RGCN.

Single-cell sequencing assay for transposase-accessible chromatin (scATAC-seq) assesses genome-wide chromatin accessibility in thousands of cells to reveal regulatory landscapes in high resolutions. However, the analysis presents challenges due to the high dimensionality and sparsity of the data. Several methods have been developed, including transformation techniques of term-frequency inverse-document frequency (TF-IDF), dimension reduction methods such as singular value decomposition (SVD), factor analysis, and autoencoders. Yet, a comprehensive study on the mentioned methods has not been fully performed. It is not clear what is the best practice when analyzing scATAC-seq data. We compared several scenarios for transformation and dimension reduction as well as the SVD-based feature analysis to investigate potential enhancements in scATAC-seq information retrieval. Additionally, we investigate if autoencoders benefit from the TF-IDF transformation. Our results reveal that the TF-IDF transformation generally leads to improved clustering and biologically relevant feature extraction.

This work concerns developing communication- and computation-efficient methods for large-scale multiple testing over networks, which is of interest to many practical applications. We take an asymptotic approach and propose two methods, proportion-matching and greedy aggregation, tailored to distributed settings. The proportion-matching method achieves the global BH performance yet only requires a one-shot communication of the (estimated) proportion of true null hypotheses as well as the number of p-values at each node. By focusing on the asymptotic optimal power, we go beyond the BH procedure by providing an explicit characterization of the asymptotic optimal solution. This leads to the greedy aggregation method that effectively approximate the optimal rejection regions at each node, while computation-efficiency comes from the greedy-type approach naturally. Extensive numerical results over a variety of challenging settings are provided to support our theoretical findings.

冠心病（CHD）是现代世界中死亡的主要原因。用于诊断和治疗CHD的现代分析工具的开发正在从科学界受到极大的关注。基于深度学习的算法，例如分割网络和检测器，通过及时分析患者的血管造影来协助医疗专业人员，在协助医疗专业人员方面发挥着重要作用。本文着重于X射线冠状动脉造影（XCA），该血管造影被认为是CHD诊断和治疗中的“黄金标准”。首先，我们描述了XCA图像的公开可用数据集。然后，审查了图像预处理的经典和现代技术。此外，讨论了共同的框架选择技术，这是输入质量以及模型性能的重要因素。在以下两章中，我们讨论了现代血管分割和狭窄检测网络，最后是当前最新技术的开放问题和当前局限性。

当网络条件恶化时，视频会议系统的用户体验差，因为当前的视频编解码器根本无法在极低的比特率下运行。最近，已经提出了几种神经替代方案，可以使用每个框架的稀疏表示，例如面部地标信息，以非常低的比特率重建说话的头视频。但是，这些方法在通话过程中具有重大运动或遮挡的情况下会产生不良的重建，并且不会扩展到更高的分辨率。我们设计了Gemino，这是一种基于新型高频条件超分辨率管道的新型神经压缩系统，用于视频会议。 Gemino根据从单个高分辨率参考图像中提取的信息来增强高频细节（例如，皮肤纹理，头发等），为每个目标框架的一个非常低分辨率的版本（例如，皮肤纹理，头发等）。我们使用多尺度体系结构，该体系结构在不同的分辨率下运行模型的不同组件，从而使其扩展到可与720p相当的分辨率，并且我们个性化模型以学习每个人的特定细节，在低比特率上实现了更好的保真度。我们在AIORTC上实施了Gemino，这是WEBRTC的开源Python实现，并表明它在A100 GPU上实时在1024x1024视频上运行，比比特率的比特率低于传统的视频Codecs，以相同的感知质量。

评估药物目标亲和力是药物发现和开发过程中的关键一步，但是在实验上获得此类数据既耗时又昂贵。因此，正在广泛开发用于预测结合强度的计算方法。但是，这些方法通常使用单任务方法进行预测，因此忽略了可以从数据中提取并用于驱动学习过程的其他信息。此后，在这项工作中，我们提出了一种多任务方法来结合强度预测。我们的结果表明，这些预测确实可以通过使用相关任务和多任务诱导的正则化的添加信息来从多任务学习方法中受益。

kronecker回归是一个高度结构的最小二乘问题$ \ min _ {\ mathbf {x}}} \ lvert \ mathbf {k} \ mathbf {x} - \ mathbf {b} \ rvert_ \ rvert_ {2}^2 $矩阵$ \ mathbf {k} = \ mathbf {a}^{（1）} \ otimes \ cdots \ cdots \ otimes \ mathbf {a}^{（n）} $是因子矩阵的Kronecker产品。这种回归问题是在广泛使用的最小二乘（ALS）算法的每个步骤中都出现的，用于计算张量的塔克分解。我们介绍了第一个用于求解Kronecker回归的子次数算法，以避免在运行时间中避免指数项$ o（\ varepsilon^{ - n}）$的$（1+ \ varepsilon）$。我们的技术结合了利用分数抽样和迭代方法。通过扩展我们对一个块是Kronecker产品的块设计矩阵的方法，我们还实现了（1）Kronecker Ridge回归的亚次级时间算法，并且（2）更新ALS中Tucker分解的因子矩阵，这不是一个不是一个纯Kronecker回归问题，从而改善了Tucker ALS的所有步骤的运行时间。我们证明了该Kronecker回归算法在合成数据和现实世界图像张量上的速度和准确性。